The 2006 Grand Prix of Houston was the second round of the 2006 Bridgestone Presents the Champ Car World Series Powered by Ford season, held on May 13, 2006, on the streets around Reliant Park in Houston, Texas.

It was the first event in Houston since a race on a downtown circuit in 2001.

Mario Domínguez won the pole, his first and only of his career, but Sébastien Bourdais came from fifth on the grid to win his second consecutive race of the season.

* The first round qualifying time for Sébastien Bourdais was disallowed after his car failed technical inspection.