The 2006 Middle Tennessee Blue Raiders football team represented Middle Tennessee State University as member of the Sun Belt Conference during the 2006 NCAA Division I FBS football season.
Led by first-year head coach Rick Stockstill, the Blue Raiders compiled an overall record of 7–6 with a mark of 6–1 in conference play, sharing the Sun Belt title with Troy.
Middle Tennessee was invited to the Motor City Bowl, the program's first bowl game at the NCAA Division I Football Bowl Subdivision (FBS) level, where they lost to Central Michigan.
The team played home games at Johnny "Red" Floyd Stadium in Murfreesboro, Tennessee.
* Note: r before the class year means that the player has used a redshirt year.