He announced that he would coach in the Sun Belt Championship Game on December 4 before departing.

On December 5, the same date as Napier's departure, Louisiana announced that then-offensive coordinator Michael Desormeaux would be promoted to head coach for the team's bowl game and the 2022 season.

Roster Last update: 22 April 2021 The 2021 schedule consists of 6 home and 6 away games in the regular season.

The Ragin' Cajuns will travel to Sun Belt foes Georgia Southern, South Alabama, Arkansas State, and Troy.

The Ragin' Cajuns will host two of the three non-conference opponents at Cajun Field, Nicholls, from NCAA Division I FCS and Ohio of the Mid-American Conference, and will travel to Texas of the Big 12 and Liberty, a FBS Independent.