The 2006 Mosconi Cup, the 13th edition of the annual nine-ball pool competition between teams representing Europe and the United States, took place 7–10 December 2006 at the Rotterdam Cruise Terminal in Rotterdam, Netherlands.

The event ended in a 12–12 draw, thus Team USA retained the Mosconi Cup as the prior year's winner.

The possibility of ties was removed for the following year's event.

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