The team completed the season with a record of ten wins and three losses that culminated in a post-season appearance in the 2007 Sugar Bowl and a number 19 ranking in the nation.

Pregame Line: ND −7.5 Georgia Tech drew first blood when quarterback Reggie Ball connected on a four-yard touchdown pass with receiver Calvin Johnson at the end of the first quarter.

Weis' gamble was rewarded when Quinn picked up the yard on a quarterback sneak, giving Notre Dame the first down and enabling them to run the clock out for the 14–10 victory.

Despite being confounded by Georgia Tech's defense all night, Notre Dame was able to seize control during the second half and walk away with the victory in its 2006 season opener.

[12] Both teams notably had a player who would go on to be better known in a different sport, for Notre Dame wide receiver Jeff Samardzija would join Major League Baseball's Chicago Cubs and Georgia Tech defensive lineman Joe Anoa'i would sign with WWE and become a multi-time world champion as Roman Reigns.

However, the Irish offense picked up in the second quarter as quarterback Brady Quinn threw two touchdown passes (his first of the season) to Jeff Samardzija and Rhema McKnight.

After a punt on Notre Dame's next drive Michigan quarterback Chad Henne threw an interception to Chinedum Ndukwe which was returned to the 4-yard line to set up a Brady Quinn touchdown pass to Ashley McConnell.

A controversial incident where Spartan players planted a flag in Notre Dame's field after Michigan State's 2005 win was talked about in the week leading up to the game.

Spartan officials said the incident occurred because Notre Dame didn't present the Megaphone Trophy after the game and players needed to celebrate.

The controversies continued into the game when a late hit on Michigan State's quarterback by the Notre Dame bench lead to a scuffle between the teams and Charlie Weis claiming an MSU player slapped him in the face.

This claim brought a penalty from the officials, and after the game John L. Smith implied that Charlie Weis had lied about a slap that could not be seen on any replay footage.

It seemed to as Notre Dame was held without a score for the entire first quarter, while the Spartans threw two quick touchdowns, one after a fumble on a punt return by Tom Zbikowski, and added a field goal before having to change sides.

In the second quarter Notre Dame switched to a no-huddle offense with worked to confuse the Spartan defense for a drive allowing Brady Quinn to throw a 32-yard touchdown to Rhema McKnight.

The second half began with a defensive stop by the Irish which allowed Quinn to throw a third touchdown of 62-yards to John Carlson to cut the Spartan lead to 10.

However, 30 seconds later, Purdue quarterback Curtis Painter threw an 88-yard touchdown pass to Selwyn Lymon to put the halftime score at 28–14, in favor of Notre Dame.

In the fourth quarter, Curtis Painter threw a 9-yard touchdown to Selwyn Lymon to give the final score of 35–21, Notre Dame winning.

Later in the quarter, Brady Quinn would throw his third touchdown of the game to tight end John Carlson to give the final margin of victory, 31–10, in favor of the Irish.

Notre Dame would cut the Bruins' lead to one when Carl Gioia capped a long, 14-play, 60-yard drive with a 33-yard field goal near the end of the third quarter.

After Aaron Perez's 59-yard punt resulted in a touchback, Notre Dame took over on its own 20-yard line with :55 remaining in the game, needing a touchdown to avoid its second loss of the season.

UCLA was unable to generate any kind of a pass rush against the Notre Dame offensive line, allowing the masterful Quinn to pick apart the Bruin defense with surgical precision.

Samardzija was quickly able to regain his footing, jumping the final yard into the end zone and scoring the winning touchdown with the ball raised aloft.

[21] Pregame Line: ND −11.5 Less Than a minute into the game Brady Quinn proved just why he's one of the top QBs in College Football today and he didn't stop there going 14 of 19 for 207 yards passing and 4 TDs.

Brady Quinn came out of halftime and with 8:33 left in the quarter threw a 23-yd pass to Marcus Freeman, but Air Force once again block Carl Gioia's XP attempt putting Notre Dame up 33–3.

[22] Pregame Line: ND −36 In the final home game for the team's senior class, the Irish took the field donning their special green jerseys.

The first quarter of the game featured good defense by both teams including a stop on 4th down by the Irish and a pick that led to 3 by Army to give the Black Knights an early 3–0 lead.

But in the second quarter the Irish came out firing and less than a minute into the 2nd Brady Quinn handed the ball to Darius Walker and he ran it in 10-yds for the Touchdown making it 7–3 Notre Dame.

With just over a minute left in the 1st half Brady Quinn hooked up with Rhema McKnight for an 8-yd touchdown reception and this time Carl Gioia hit the PAT giving Notre Dame a 20–3 lead going into halftime.

The Irish kept up the offensive onslaught to start off the 2nd half, scoring a touchdown when receiver David Grimes recovered teammate Darius Walker's fumble in the endzone to give Notre Dame a 27–3 lead.

After the Irish were held, Booty threw a 43-yard touchdown pass to Dwayne Jarrett to give the Trojans a 37–17 lead (Danelo missed the extra point).

[33] Five players were named by Sports Illustrated, including Quinn on the second team, and Jeff Samardzija, Rhema McKnight, John Carlson, and Geoff Price as honorable mentions.