The 2006 Ole Miss Rebels football team represented the University of Mississippi as a member of the Western Division of the Southeastern Conference (SEC) during the 2006 NCAA Division I FBS football season.
Led by second-year head coach Ed Orgeron, the Rebels compiled an overall record of 4–8 with a mark of 2–6 in conference play, tying of fourth place in the SEC's Western Division.
Ole Miss played home games at Vaught–Hemingway Stadium in Oxford, Mississippi.
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