The 2006 Time Warner Cable Road Runner 225 was the fourth round of the 2006 Bridgestone Presents the Champ Car World Series Powered by Ford season, held on June 4, 2006, on the Milwaukee Mile oval in West Allis, Wisconsin.

Sébastien Bourdais took the pole and the win, his fourth consecutive victory to open the year.

It was the final CART/Champ Car event to take place on an oval prior to the reunification of American open-wheel racing in 2008.

* Mario Domínguez was stripped of his points for this race for avoidable contact during the first lap of the race.

† The car of Alex Tagliani was withdrawn from the event after heavy contact with the wall damaged his car beyond repair during the first practice period.