The 2006 Campeonato Nacional Clausura Copa Banco del Estado was the 80th Chilean League top flight, in which Colo-Colo won its 25th league title after beating Audax Italiano in the finals.

[1]

Lota Schwager reached its promotion to Primera División after beating Rangers in the 2nd leg match’s penalty shoot-out at Coronel.

[2] Whilst Palestino remained in the top level after beating Arturo Fernández Vial 3–1 in Concepción and 1–0 in La Cisterna, Santiago.

[3]