Phil Taylor was the defending champion but got knocked out at the quarter-final stage by Raymond van Barneveld.

In addition there were eight UK Open Regional Finals for the "professional" players.

The results of the eight qualifiers were then collated into an Order of Merit table (Winner £4000; Runner-up £2000; 3–4 £1000; 5–8 £500; 9–16 £250; 17–32 £100; 33–64 £50).

The top 96 players plus ties in this Order of Merit join the 32 Greene King qualifiers at the televised stages in Bolton.

25 September 2005 (Welsh) Mark Walsh 2–1 Phil Taylor [1] 23 October 2005 (Irish) Colin Lloyd 2–1 Andy Smith [2] 6 November 2005 (Scottish) Adrian Lewis 2–0 Colin Lloyd [3] 8 January 2006 (North East) Kevin Painter 2–0 Colin Lloyd [4] 12 February 2006 (South West) Mark Dudbridge 2–0 Dennis Priestly [5] 5 March 2006 (Southern) Chris Mason 2–1 Barrie Bates [6] 19 March 2006 (North West) Alan Tabern 2–1 Steve Maish [7] 9 April 2006 (Midlands) Raymond van Barneveld 2–0 Ronnie Baxter [8] [9]