[4] Despite the loss of graduated 1st Team All-American and GLVC Player of the Year Alicia DeShasier, good things were expected of the Cougars.

[10] The Cougars entered the double-elimination Great Lakes Valley Conference at EastSide Centre in East Peoria, Illinois as the #2 seed.

After Lewis defeated Missouri–Rolla in the second semifinal, the Cougars won the Final to earn the GLVS's automatic bid to the NCAA Division II Tournament.

[12] SIUE arrived at the Division II Women's College World Series at Firestone Stadium in Akron, Ohio on a 12-game winning streak.

The Cougars finally managed to score in the top of the twelfth inning, then held on to win the 2007 NCAA Division II Softball Championship.

[12][13] In the Great Lakes Regional, Kaitlin Colosimo threw her second no-hit game of the season versus Wayne State[7] and was named the Most Outstanding Player of the tournament.

She was joined on the All-Tournament Team by outfielders Jodie Ohlau and Courtney Mall, catcher Libby Lenart, and shortstop Kaeleigh Rousey.

[14] In the Women's College World Series, Kaitlin Colosimo threw her third no-hitter against Lock Haven in the first semifinal[7] and was again named the Most Outstanding Player of the tournament.