The arena was built in the fall of 1971 to serve as the host facility for UMSL's intercollegiate athletics and recreation and intramural activities.

In 1986, the arena underwent a face lift with the installation of new bleachers, including chair-back seats on the lower level.

In fall of 2006, due to storm damage, the gym floor was completely replaced with all new support and wood surface.

In addition to Triton athletics the Mark Twain Building has hosted other events included the MHSAA boys and girls basketball tournament games, and in the summer of 2002 it served as the home gym for the St. Louis Skyhawks of the United States Basketball League.

It is located on UMSL's South Campus and includes an elevated pressbox with covered bleacher seating behind home plate for 200 and room for lawn seating along either side with a modern sound system, a full-sized electronic scoreboard which sits in left field, dugouts and bullpens for each team, and an infield tarp to protect against inclement weather.