The season kicked off on Friday, April 13 when the 2006 league runners-up Rochester Raging Rhinos traveled to the Juan Ramon Loubriel Stadium in Bayamón to take on the Puerto Rico Islanders.
The schedule was not a balanced home and away affair; to make up the four extra games to total 28, each team played their four geographically closest competitors.
The playoff format was changed to qualify eight instead of six teams; therefore the first and second league champions obtained seeding to determine home field advantage instead of a first round bye as in previous seasons.
The previous bidding to host between the two playoff finalists for the one game cup final was discontinued for this season.
First Team F: Dan Antoniuk (Atlanta Silverbacks); Hamed Diallo (Rochester Raging Rhinos); Sebastien Le Toux (Seattle Sounders) (MVP & Co-Leading Goalscorer) M: Stephen Armstrong (Charleston Battery); Andrew Gregor (Portland Timbers); Martin Nash (Vancouver Whitecaps); Zinho (Miami FC) D: Gabriel Gervais (Montreal Impact); David Hayes (Atlanta Silverbacks) (Defender of the Year); Cameron Knowles (Portland Timbers) G: Josh Wicks (Portland Timbers) (Goalkeeper of the Year) Coach: Gavin Wilkinson (Portland Timbers) (Coach of the Year) Second Team F: Charles Gbeke (Montreal Impact) (Co-Leading Goalscorer); Roger Levesque (Seattle Sounders) M: Leonardo Di Lorenzo (Montreal Impact); Brian Farber (Minnesota Thunder); Kupono Low (Carolina RailHawks); Johnny Menyongar (Rochester Raging Rhinos) D: Taylor Graham (Seattle Sounders); Steve Klein (Vancouver Whitecaps); Scot Thompson (Portland Timbers); Marco Velez (Puerto Rico Islanders) G: Matt Jordan (Montreal Impact)