The 2008–09 season was the 91st season in the history of U.S. Lecce and the club's first season back in the top flight of Italian football.

In addition to the domestic league, Lecce participated in this season's edition of the Coppa Italia.

The season covered the period from 1 July 2008 to 30 June 2009.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.