The 2008 Challenge Cup (also known as the Carnegie Challenge Cup for sponsorship reasons) was the 107th staging of the most prestigious knock-out competition in the world of Rugby league, featuring teams from across Europe, including England, Scotland, Wales, France and Russia.

St. Helens successfully defended their title after beating Hull F.C.

Vereya were runners-up in the Russian Championship to Lokomotiv Moscow.

The National Leagues teams, together with Lokomotiv Moscow, Pia, Lezignan and Toulouse joined in this round.

From Round 4 onwards, the competition was a straightforward knock-out, with no more teams joining.