They finished the regular season tied with the Minnesota Twins (88–74) and won a one-game playoff for the division title.

They subsequently lost the 2008 American League Division Series to Tampa Bay Rays.

Gavin Floyd nearly threw a no-hitter against the Minnesota Twins on May 6, broken up by Joe Mauer's double in the ninth inning.

Finishing fourth in the American League Central division coupled with having both MLB's lowest batting average and on-base percentage in 2007 prompted the White Sox to make numerous transactions, particularly with West Coast teams, to improve their lineup.

Other players no longer with the team from the 2007 season are Alex Cintrón, Darin Erstad (signed with Houston), Andy González, Mike Myers, Heath Phillips, Scott Podsednik, and Luis Terrero.