At the green flag, Hélio Castroneves took the lead in turn 1 from polesitter Scott Dixon.

After another sequence of pit stops, Kanaan led Dan Wheldon and Marco Andretti.

John Andretti's pitcrew had trouble engaging the fuel hose, and he dropped back the end of the running order.

Most of the leaders pitted, but Wheldon, Hideki Mutoh, and Danica Patrick stayed out to lead the field.

On the lap 227 restart, Marco Andretti and Dixon passed Patrick to take third and fourth place respectively.