The 2010–11 season of the Belgian Second Division (also known as EXQI League for sponsorship reasons) started on Wednesday 18 August 2010 and finished in May 2011.
OH Leuven won the title on the penultimate matchday after a 2–2 draw away to Antwerp.
The three period winners take part in the Belgian Second Division final round together with the winner of the 2010–11 Belgian Pro League relegation playoff.
The winner of this final round gets to play in the 2011–12 Belgian Pro League.
In case one or more periods are won by the team winning the league or in case one team wins multiple periods, the extra places go the teams finishing the highest in the league not already qualified.