The Bulls, led by twelfth-year head coach Reggie Witherspoon, played their home games at Alumni Arena in Amherst, New York as members of the Mid-American Conference (MAC).

[1] Buffalo hosted unanimous national college player of the year Jimmer Fredette and the 16th-ranked BYU Cougars at Alumni Arena on December 30, 2010.

In the CIT, Buffalo won its first two games before losing in the quarterfinals against eventual runner-up Iona.

At the end of the season, McCrea would be the first Buffalo player named the MAC Freshman of the Year.

[5] Four-year captain Byron Mulkey, a senior from Niagara-Wheatfield High School, set a program record with 85 steals in the final season of his college basketball career.