The season is split into two tournaments—the Torneo Apertura and the Torneo Clausura—each with identical formats and each contested by the same eighteen teams.

Guadalajara began their season on July 24, 2010, against Puebla, Guadalajara played their homes games on Saturdays at 7:00pm local time.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Source: Apertura 2010 results Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.