The season covered the period from 1 July 2010 to 30 June 2011.

This is a list of the significant events to occur at the club during the 2010–11 season, presented in chronological order.

This list does not include transfers, which are listed in the transfers section below, or match results, which are in the results section.

June: July: August: April: Preston North End are relegated to League One after a 1–0 defeat to Cardiff City.

Source: PNEFC Championship Results Notes: Player substitutions are not included.