The 2010–11 Standard Bank Pro20 was the eighth season of the Standard Bank Pro20 Series, established by the Cricket South Africa and the eighth season of the CSA T20 Challenge overall.

In the group stage, teams face each other in a single round-robin tournament.

At the end of the group stage, the top four teams qualify for the semi-finals.

If a match in the knockout stage ends with a tie, a Super Over will determine the winner.

In the knockout stage, the higher seed hosts the second and third (if required) matches while the lower seed hosts the first match.