The 2010 Telkom Knockout was a football (soccer) knockout competition which comprised the 16 teams in the South African Premier Soccer League.
Kaizer Chiefs won their 9th title, by defeating Orlando Pirates 3–0 in the final at Soccer City.
If teams are tied at full-time, then extra time is played; penalties will decide the winner if the scores are still even (there is no golden goal rule).
The 16 teams that competed in the Telkom Knockout competition are: (listed in alphabetical order).
The draw for the semi-finals was done on 7 November 2010, following the Maritzburg United vs Mamelodi Sundowns match.