The 2010–11 Texas Southern Tigers basketball team represented Texas Southern University during the 2010–11 NCAA Division I men's basketball season.

The Tigers, led by 3rd-year head coach Tony Harvey, played their home games at the Health and Physical Education Arena and were members of the Southwestern Athletic Conference.

They defeated Arkansas–Pine Bluff in the quarterfinals of the SWAC Basketball tournament before being upset by eventual champion Alabama State in the semifinals.

The Tigers finished the 2009–10 season 17–16 overall; 11–7 in SWAC play.

They were not invited to either the NCAA tournament or the NIT.