The 2020–21 Texas Southern Tigers basketball team represented Texas Southern University during the 2020–21 NCAA Division I men's basketball season.

The Tigers were led by third-year head coach Johnny Jones and played their home games at the Health and Physical Education Arena in Houston, Texas, as members of the Southwestern Athletic Conference (SWAC).

They received the conference’s automatic bid to the NCAA tournament where they defeated Mount St Mary’s in the First Four before losing in the first round to Michigan.

[1][2] The Tigers defeated Grambling State in the quarterfinals of the SWAC tournament.

[3] The remainder of the tournament was cancelled by the National Collegiate Athletic Association due to the COVID-19 pandemic on March 12, 2020.