The season began on 13 August 2010 and concluded on 11 May 2011 with Conwy United as Division 1 champions, Llanberis were relegated to Division 2.
In Division 2, Caernarfon Wanderers were champions with Bodedern Athletic as runners-up.
Rhydymwyn were champions in the previous season and were promoted to the Cymru Alliance and replaced by Holyhead Hotspur, Bethesda Athletic, Denbigh Town, Llanfairpwll and Caernarfon Town who were all relegated from the Cymru Alliance.
Blaenau Ffestiniog Amateur, Llandyrnog United, Nantlle Vale, Amlwch Town and Halkyn United were relegated to the newly formed Division 2.
Last season bottom 5 teams: Blaenau Ffestiniog Amateur, Llandyrnog United, Nantlle Vale, Amlwch Town and Halkyn United were relegated and joining them to form the new Division 2 were Bodedern Athletic, Caernarfon Wanderers, Connah's Quay Town, Gaerwen, Greenfield and Penmaenmawr Phoenix.