The Rangers went on to defeat the Yankees in the ALCS, then lose the 2010 World Series to the National League champion San Francisco Giants.

The Rangers got on the board in the second off of Rays ace David Price when Ian Kinsler hit a leadoff single and scored on Jeff Francoeur's double.

In the ninth inning, pitching in a non-save situation, Rangers closer Neftalí Feliz walked the first two batters, but then settled down and induced a lineout from Ben Zobrist before striking out Reid Brignac and Matt Joyce to end the game.

After a controversial checked swing call, Michael Young hit a three-run home run to extend the lead to 5–0.

However, Kelly Shoppach and Matt Joyce both struck out, then Jason Bartlett hit a fly ball to center field to end the threat.

In seeking their first franchise postseason home game win and series sweep, the Rangers sent Colby Lewis to the mound to face the Rays' Matt Garza.

Mitch Moreland hit a lead-off double in the bottom of the third inning, advanced to third on a passed ball by Rays catcher John Jaso, then scored on Elvis Andrus's RBI ground-out.

Ian Kinsler's go-ahead homer in the bottom of the seventh inning took the lead for the Rangers and also knocked Garza out of the game.

Rays designated hitter Dan Johnson doubled in the top of the eighth inning, then Peña's RBI single scored pinch-runner Desmond Jennings to tie the game at 2–2.

Evan Longoria hit a two-run homer off Rangers reliever Derek Holland in the fifth inning to increase the Rays' lead to five.

The Rangers showed some sign of life when Nelson Cruz hit a home run, his third in this series, in the bottom of the sixth inning.

Balfour got out of the inning and pitched a scoreless seventh, before handing it over to setup man Joaquín Benoit, a Ranger until this year.

Elvis Andrus led off the game with a single, later stole second, and scored for the Rangers on Josh Hamilton's RBI ground-out in the top of the first inning.

The Rays tied up the game in the bottom of the third inning when Sean Rodriguez scored on Ben Zobrist's RBI single.

In the top of the fourth inning, Nelson Cruz hit a two-out double that barely missed being a home run in the deepest corner of the field, stole third, then scored on Rays' catcher Kelly Shoppach's throwing error.

In the bottom of the second inning, Yankee starter CC Sabathia hit the leadoff hitter, Jim Thome, then allowed a two-run home run by Michael Cuddyer.

The Yankees tied the game in the top of the fourth inning, as Curtis Granderson doubled, advanced to third base on Mark Teixeira's single, then scored on Alex Rodriguez's sacrifice fly.

In the top of the seventh inning, Berkman's RBI double over the head of Twins center fielder Denard Span once again took the lead for the Yankees.

Like Joe Maddon did earlier in the Rangers–Rays game, Twins manager Ron Gardenhire argued about the 1–2 borderline pitch right before Berkman's double and got ejected.

In the bottom of the ninth inning, Mariano Rivera gave up a leadoff single to Joe Mauer, but got Delmon Young to ground into a double play and then induced a fly ball to left field from Jim Thome for the second consecutive save in the series.

[15] The Yankees took an early lead this time in the bottom of the second inning when Robinson Canó hit a lead-off triple, later scored on Jorge Posada's RBI single.

Nick Swisher hit a two-out double in the bottom of the third inning, then scored on Mark Teixeira's RBI single to increase their lead to two.

The next batter, Marcus Thames, who had a successful record against left-hander Brian Duensing this year, hit the first pitch he saw into right field.

However, Yankees relievers Boone Logan and David Robertson induced a popout and a flyout respectively to get out of the one-out bases-loaded jam.