As a player, Boone is most recognized for his 2003 campaign with the Yankees, during which he hit the winning walk-off home run of the 2003 American League Championship Series.

He began serving as the Yankees' manager in 2018, leading the team to two 100-win records during his first two seasons and playoff appearances in the first five.

The California Angels selected Boone on the third day of the 1991 MLB draft, but he had no intention to sign a professional contract.

[5] Boone made his MLB debut in June 1997,[6] and was ejected from the game after being called out sliding into home.

[12] The New York Yankees acquired Boone from the Reds for Brandon Claussen, Charlie Manning, and cash on July 31, 2003.

[14] During Game 7 of the 2003 American League Championship Series (ALCS), Boone hit a walk-off home run in the 11th inning, off Tim Wakefield, which gave the Yankees a 6–5 victory over the Boston Red Sox, thus prolonging the Curse of the Bambino.

"[16] In January 2004, Boone tore the anterior cruciate ligament in his left knee during a pick-up basketball game.

The game violated the standard MLB player contract, which forbids taking part in off-season basketball, skiing, and surfing.

In March 2009, Boone underwent open-heart surgery to replace a bicuspid aortic valve, a condition that he has been aware of since childhood, but which routine tests indicated had recently worsened.

[27][28][29] Boone returned to baseball on August 10, when he began his rehabilitation with the Corpus Christi Hooks, the Astros' Double-A minor league affiliate.

[34] Boone called the 2014 and 2015 World Series for ESPN Radio with play-by-play announcer Dan Shulman.

[36] After the 2017 season, the Yankees decided not to retain Joe Girardi as their manager; they hired Boone to succeed him on December 4, 2017.

[41] He finished his first season with a 100–62 record,[42] good for second in the American League East,[42] and led the Yankees to the wild card game against the Oakland Athletics, despite losing star outfielder and team leader Aaron Judge for two months with a wrist injury.

On October 3, 2018, the Yankees defeated the Athletics 7–2 to advance to the American League Division Series,[43] giving Boone his first postseason win as a manager.

Due to the COVID-19 pandemic, the Yankees and the other 29 Major League Baseball teams only played a 60-game regular season.

[45] Following the winning streak, the team stumbled, going 3–12 between August 28 and September 12,[46] and finished tied for second in the American League East behind the Tampa Bay Rays, but lost the wild card game to the Boston Red Sox 6–2.

They beat the Cleveland Guardians in five games, but got swept by the Houston Astros in the ALCS, marking Boone's fifth-straight playoff exit.

[50] As of June 9, Boone has the third-highest ejection rate in MLB history among managers, behind only Paul Richards and Frankie Frisch, and ahead of Earl Weaver, Bobby Cox, and Ron Gardenhire, managers who were all known for their proclivity for getting ejected.