The 2010 Conference USA football season was an NCAA football season played from September 2, 2010, through December 31, 2010.

Conference USA consists of 12 football members separated into 2 divisions: East Carolina, Marshall, Memphis, Southern Miss, UAB, and UCF make up the eastern division, while Houston, Rice, SMU, Tulane, Tulsa, and UTEP comprise the western division.

Although C-USA was founded in 1995, it did not start football competition until 1996.

[2] East Carolina won the 2009 conference championship for the second straight year defeating the #21 Houston Cougars 38–32.

[3] No Conference USA teams were ranked though both SMU and UCF each received one vote.