The 2010 Gardner–Webb Runnin' Bulldogs football team represented Gardner–Webb University as a member of the Big South Conference during the 2010 NCAA Division I FCS football season.

Led by Steve Patton in his 14th-year and final season as head coach, the Runnin' Bulldogs compiled an overall record of 4–7 with a mark of 2–4 in conference play, tying for fourth place in the Big South.

Gardner–Webb played home games at Ernest W. Spangler Stadium in Boiling Springs, North Carolina.

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