The 2010 Presbyterian Blue Hose football team represented Presbyterian College as a member of the Big South Conference during the 2010 NCAA Division I FCS football season Led by second-year head coach Harold Nichols, the Blue Hose finished the season with an overall record of 2–9 and a mark of 1–5 in conference play, tying for sixth place in the Big South.

Presbyterian was later vacated both wins from the season because the team has used an ineligible player.

The Blue Hose played home games at Bailey Memorial Stadium in Clinton, South Carolina.

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