Georgia State played their first-ever season of football in 2010 and were classified as an independent school, meaning they had no athletic conference affiliation.

Bill Curry guided the new program's team to a 6–5 record, while all of their home games are played in the Georgia Dome.

The Panthers played their first football game at home (the Georgia Dome) on September 2, 2010, against Shorter University (Mid-South Conference) (NAIA).

[2] The Panthers football program gained national exposure when it played 10th ranked Alabama of the FBS on November 18.

Over 100,000 people attended the game held in Bryant–Denny Stadium in Tuscaloosa, and it was broadcast live on the ESPNU television network.