The 2010 South Alabama Jaguars football team represented the University of South Alabama in the 2010 college football season.

They were led by second-year head coach Joey Jones and played their home games at Ladd–Peebles Stadium, located in Mobile, Alabama.

Continuing the Jaguars' immersion into NCAA Division I football, the Jaguars increased their schedule to ten games from seven in their inaugural season, dropped all of their prep school opponents, played three of their ten contests on the road, and played against four FCS opponents.

The Jaguars completed their second season with an undefeated record of ten wins and zero losses (10–0).

This college football 2010s season article is a stub.