It took place on the weekend of August 27–29, 2010 at the Indianapolis Motor Speedway.

During a support event for MotoGP, the second of two United States Grand Prix Racer Union 250cc (age 12–18) races during the race meet on August 29, 13-year-old Peter Lenz was killed during the warmup lap before the start.

[4] An eight-motorcycle crash in the Snake Pit at the start (#34 R. Hayden, #29 Iannone, #2 Talmácsi, #52 Pešek, #61 Ivanov, #3 Corsi, #48 Tomizawa, #56 Ranseder) led to a red flag and two retirements (Tomizawa and Ranseder) immediately.

[8] Marc Márquez was given a 20-second penalty after the race for cutting the track.

[9] Below are the standings for the top five riders and constructors after round eleven has concluded.