The 2010 LPGA Championship was the 56th LPGA Championship, held June 24–27 at Locust Hill Country Club in Pittsford, New York, a suburb southeast of Rochester.

Known for sponsorship reasons as the LPGA Championship presented by Wegmans, it was the second of four major championships on the LPGA Tour during the 2010 season.

The champion was Cristie Kerr, age 32, with a 269 (−19) to win by twelve strokes over Song-Hee Kim.

It was Kerr's second major championship and fourteenth career win on the LPGA Tour, and vaulted her from fifth to first in the world rankings.

[2] This was the first of four consecutive years the LPGA Championship was played at Locust Hill; the previous five editions were played at Bulle Rock Golf Course in Havre de Grace, Maryland.