She learned to play golf on the Children's Course and North Berwick West Links in the town.

[17] and was a member of the victorious International team captained by Annika Sörenstam in the inaugural Lexus Cup.

[21] On 2 August 2009 at Royal Lytham & St Annes, Matthew won the Ricoh Women's British Open with a final score of 3-under-par over second-place finisher Karrie Webb.

[22] On 13 November 2011, Matthew won her fourth LPGA title at the Lorena Ochoa Invitational in Mexico.

At the 2013 LPGA Championship, Matthew finished runner-up after losing a sudden-death playoff against the world number one Inbee Park.

[23] In July 2016, Matthew was named as a vice-captain for the 2017 Solheim Cup[24] but ended up playing in the match after an injury to Suzann Pettersen.

On 6 September 2021, Matthew led the European team to defeat the US at the Inverness Club, Toledo, Ohio.

[27] In July 2009, Matthew and her husband escaped a fire at the hotel they were staying in while she played in the Evian Masters.

^ The Women's British Open replaced the du Maurier Classic as an LPGA major in 2001.