The 2010 Lory Meagher Cup is the second edition of the Lory Meagher Cup since its establishment by the Gaelic Athletic Association in 2009 and is the fourth-tier of Hurling for senior county teams (the All-Ireland Senior Hurling Championship is the first-tier trophy).
It is contested by eight GAA county teams ranked 30–36 in the 2010 All-Ireland Senior Hurling Championship.
The teams competing were Cavan, Donegal, Fermanagh, Leitrim, Longford, South Down, and Warwickshire.
The 2009 champions, Tyrone were promoted to the 2010 Nicky Rackard Cup, and did not have the opportunity to defend their title.
The tournament had a double elimination format - each team played at least two games before being knocked out.