The 2010 Louisiana Tech Bulldogs football team represented Louisiana Tech University as a member of the Western Athletic Conference (WAC) during the 2010 NCAA Division I FBS football season.

Led by first-year head coachSonny Dykes, the Bulldogs played their home games at Joe Aillet Stadium in Ruston, Louisiana.

Louisiana Tech finished the season with a record of 5–7 overall and a mark of 4–4 in conference play, placing fifth in the WAC.