The 2010 NCAA Division II men's basketball tournament involved 64 schools playing in a single-elimination tournament to determine the national champion of men's NCAA Division II college basketball as a culmination of the 2009–10 basketball season.

The tournament was won by the California State Polytechnic University, Pomona (Cal Poly Pomona) men's basketball team, which defeated Indiana University of Pennsylvania, 65–53, in the title game.

The championship was the first in the Broncos' history after ending runner-up in 2009.

[1] Location: Taylor Center Host: Minnesota State University, Mankato Location: D.L.

Ligon Coliseum Host: Midwestern State University Location: Memorial Field House Host: Indiana University of Pennsylvania Location: Tucker Coliseum Host: Arkansas Tech University Location: Owensboro Sportscenter Host: Kentucky Wesleyan College Location: Sam Carver Gymnasium Host: Western Washington University Location: Merkert Gymnasium Host: Stonehill College Location: Christenberry Fieldhouse Host: Augusta State University Location: MassMutual Center Hosts: American International College and Naismith Memorial Basketball Hall of Fame