The Yankees were attempting to defend its status as American League and World Series champions, but lost in the ALCS to the Texas Rangers.

The Yankees' regular season record for 2010 was 95 wins, 67 losses, second place in the American League East behind Tampa Bay and good for the AL Wild Card.

On May 8, Mark Teixeira hit 3 home runs against the Red Sox, becoming only the second Yankee player in history since Lou Gehrig to accomplish the feat.

[18] Brett Gardner became the first player in MLB history to hit a grand slam and an inside-the-park home run during back-to-back games on July 3–4.

[20] On July 25, Robinson Canó recorded his 1,000th career hit, becoming the third-quickest homegrown Yankees player – behind Derek Jeter and Don Mattingly – to reach that plateau.

He is the first Yankee to hold the Major League lead in hits among active players since Johnny Mize in 1952, according to the Elias Sports Bureau.

[24] On August 22, Sabathia recorded his 16th consecutive start of at least six innings allowing three earned runs or less, breaking a tie with Ron Guidry (from his Cy Young Award-winning 1978 season for the longest streak in franchise history).

Also on this date, Mark Teixeira and A-Rod, who have been teammates for 3 years (2003 with Rangers, and 2009–10 with Yankees), hit two home runs in a game each for the first time.

However, they lost the division crown to the Tampa Bay Rays on the last day of the season after an 8–4 loss to the Red Sox, thus they were the Wild Card.

Friday, October 15, 2010 – 8:00 p.m. (EDT) at Rangers Ballpark in Arlington in Arlington, Texas Saturday, October 16, 2010 – 4:00 p.m. (EDT) at Rangers Ballpark in Arlington in Arlington, Texas Monday, October 18, 2010 – 8:00 p.m. (EDT) at Yankee Stadium in the Bronx, New York Tuesday, October 19, 2010 – 8:00 p.m. (EDT) at Yankee Stadium in the Bronx, New York Wednesday, October 20, 2010 – 4:07 p.m. (EDT) at Yankee Stadium in the Bronx, New York Friday, October 22, 2010 – 8:07 p.m. (EDT) at Rangers Ballpark in Arlington in Arlington, Texas Note: G = Games played; AB = At bats; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; SB = Stolen bases; BB = Walks; AVG = Batting average; SLG = Slugging percentage Source:[1] Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Runs allowed; ER = Earned runs allowed; BB = Walks allowed; SO = Strikeouts Source:[2] LEAGUE CHAMPIONS: Tampa