The 2010 North Dakota State Bison football team represented North Dakota State University in the 2010 NCAA Division I FCS football season.

The Bison were led by eighth-year head coach Craig Bohl and played their home games at the Fargodome.

They were a member of the Missouri Valley Football Conference.

[1] The Bison were not expected to make the playoffs but managed enough votes to get in.

The Bison were driving down the field and were on the 5-yard line when quarterback Brock Jensen ran and appeared to be down at the 1-yard line; the play was called a fumble and recovered by Eastern Washington.