The 2010 Indiana State Sycamores football team represented Indiana State University as a member of the Missouri Valley Football Conference (MVFC) during the 2010 NCAA Division I FCS football season.

Led by third-year head coach Trent Miles, the Sycamores compiled an overall record of 6–5 with a mark of 4–4 in conference play, tying for third place in the MVFC.

Indiana State played home games at Memorial Stadium in Terre Haute, Indiana.

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