The eleventh edition of the Pan Pacific Swimming Championships, also known as the 2010 Mutual of Omaha Pan Pacific Swimming Championships, a long course (50 m) event, was held in Irvine, California, United States, from August 18–22.

[1] *   Host nation (United States)By agreement of the charter nations, medals from the 50 m backstroke, breaststroke, and butterfly events would not count towards the official medals standings.

These events are not typically swum at the Pan Pacific Championships, but were added to the schedule because the meet served as a qualifying meet for several other large international competitions.

[2] The swimming program for 2010 had a total number of 42 events (21 each for men and women).

Prior to FINA's creation of semi-finals in the late 1990s, a total of 3 swimmers per country could qualify for the final and consolation heats of an event, with no more than 2 swimmers per country in a final or consolation.