The 2010 Portuguese motorcycle Grand Prix was the penultimate round of the 2010 Grand Prix motorcycle racing season.

The 125cc race was red-flagged after 7 laps due to rain.

It was later restarted for 9 laps, with the grid determined by the running order before the suspension.

The second part of the race determined the final result.

[5] Below are the standings for the top five riders and constructors after round seventeen has concluded.