The Liguilla (English: Mini League) of the Primera División de México 2010 Bicentenario was a final mini-tournament involving eight teams of the Primera División de México, in an elimination two-legs playoff.
Defending champions Monterrey, were not able to defend their past championship, as they were knocked out in the first round of the "Liguilla" by Pachuca As the 18 teams of the 2010 Bicentenario were divided in three groups of six teams, it was determined that the two top of each group advanced to the Liguilla, even though having had a low performance at the general table.
The Liguilla has a particular tie-breaking criteria: In case of a tie in the aggregate score, the higher seeded team advance.
In this case, if the teams remained tied after 90 minutes of play during the second leg of the finals, extra time were used, followed by a penalty shootout if necessary.
The teams were seeded one to eight in quarterfinals, and re-seeded one to four in semifinals, depending on their position at the general table of the season.