2010 Regional League Division 2 Bangkok Metropolitan Region is the 2nd season of the League competition since its establishment in 2009.
It is in the third tier of the Thai football league system.
Raj Pracha-Nonthaburi were promoted to the 2010 Thai Division 1 League after winning the 2009 Regional League Division 2 championship pool.
Thai Summit Samut Prakan and Rose Asia Pathum Thani re-located from the Regional League Central-East Division 2009 Nonthaburi and North Bangkok College joined the newly expanded league setup.
Sarawitaya dropped out of the league at the end of the 2009 campaign.