2010 Regional League Division 2 Northern Region is the second season of the League competition since its establishment in 2009.
It is in the third tier of the Thai football league system.
Chiangrai United were promoted to the 2010 Thai Division 1 League after coming 2nd in the 2009 Regional League Division 2 championship pool.
Nakhon Sawan were relegated from the 2009 Thai Division 1 League after finishing the season in 16th place.
Phrae renamed Phrae United Chiangmai United renamed Chiangmai Chiangrai, Lampang, Phayao and Uthai Thani joined the newly expanded league setup.