The 2010 Sacramento State Hornets football team represented California State University, Sacramento as a member of the Big Sky Conference during the 2010 NCAA Division I FCS football season.

Led by fourth-year head coach Marshall Sperbeck, Sacramento State compiled an overall record of 6–5 with a mark of 5–3 in conference play, placing in a three-way tie for third in the Big Sky.

This was the first winning season for the Hornets since the 2000 team finished 7–4.

[12] No Sacramento State players were selected in the 2011 NFL draft.

[13][14][15] The following finished their college career in 2010, were not drafted, but played in the NFL.