The 2010 Segunda División season was the 65th edition of the second tier of Federación Peruana de Futbol.
The champion, Cobresol, was promoted to the 2011 Torneo Descentralizado.
In February 2010, IDUNSA signed a strategic alliance with the club Carlos A. Mannucci, by the product of this "strategic alliance" IDUNSA will pass to be called Carlos Mannucci and light up the classical colors of the tricolor.
[1] Weeks later, the alliance was canceled due to that the ADFP-SD did not accept the change of headquarters.
On May 28, 2010, IDUNSA and Sport Águila withdrew before the start of the season.