The 2010 Shepherd Rams football team represented Shepherd University as a member of the West Virginia Intercollegiate Athletic Conference (WVIAC) during the 2010 NCAA Division II football season.
Led by 24th-year head coach Monte Cater, the Rams compiled an overall record of 12–2 with a conference mark of 7–1, winning the WVIAC title.
Shepherd advanced to the NCAA Division II playoffs, where they beat Shaw in the first round, Kutztown in the second round, and Mercyhurst in the quarterfinals before losing in the semifinals at Delta State.
The Rams went 9–1 in the regular season and advanced to the 2010 NCAA Division II football playoffs.
[2] The team then went on to win two straight games on the road, against Kutztown and Mercyhurst, before losing in the semifinal round to Delta State.