USC finished second in the Southeastern Conference regular season standings, and received an at-large bid to the 2010 NCAA Division I baseball tournament.

The Gamecocks beat Coastal Carolina in two games to win the Myrtle Beach Super Regional and advance to the 2010 College World Series.

Overall, Carolina played nine schools that would eventually make the 2010 NCAA tournament (Alabama, Arkansas, Auburn, The Citadel, Clemson, College of Charleston, Florida, Mississippi, Vanderbilt).

Facing Bulldog ace and MLB first-round draft pick Asher Wojciechowski, USC would again come from behind, scoring five in the seventh and another two in the ninth to overcome a 4–2 deficit for the 9–4 victory, riding Blake Cooper's career-high 12 strikeouts.

Trailing the Chanticleers 9–7 in the eighth, freshman first-baseman Christian Walker became an instant hero with a 3-run blast that led to a 10–9 victory and a ninth trip to Omaha for South Carolina.

[7] Playing out of the losers' bracket with no margin for error, Carolina drubbed #1 national seed Arizona State 11–4 on June 22, scoring eight runs in the second inning to send the Sun Devils home.

On June 25, Michael Roth made his first pitching start in over a year for the Gamecocks, and shut down the red-hot bats of the Tigers with a three-hit, complete-game performance in a dominating 5–1 victory.

[11] The Gamecocks and the Bruins were both playing for the first baseball national championship for either school, and Carolina put themselves in the driver's seat as they cruised to a 7–1 victory in the first game of the series.

The respective closers for the two teams would continue the pitching battle for another three innings, until the bottom of the 11th when Scott Wingo drew a leadoff walk, advanced to second on a passed ball and was moved to third on a sacrifice bunt.